PhD offer at the Toulouse Institute of Pharmacology and Structure Biology

The Ph.D. student will be enrolled in the CARe program.

Deadline for application:  April 20th 2024

Starting date: September/October 2024

Working Place

The IPBS (Institute of Pharmacology and Structure Biology) is a joint research unit of the National Center for Scientific Research (CNRS), and the University of Toulouse. IPBS is located in Toulouse, a vibrant city in the south of France. The IPBS provides an ambiance that fosters equality, diversity, and inclusivity, and hosts about 250 scientific and administrative staff, including Ph.D. students and post-doctoral fellows of multiple nationalities. IPBS comprises 18 research teams, and the work carried out at the institute is dedicated to the discovery of new therapeutic targets in the fields of cancer, infectious diseases, and inflammatory diseases: https://www.ipbs.fr/. The selected Ph.D. candidate will submit his/her application to the CARe Ph.D. 2024 open call with the research team “Epigenetic Mechanisms in Cancer,” led by Priyanka Sharma at the IPBS, Toulouse. The candidate will be getting the promising opportunity to work on a multidisciplinary project on cancer and transcription biology in cancer using the advantage of genomics and biophysics techniques. 

Technical methods

  • Single-cell RNA transcriptomics.
  • Live cell imaging and machine learning tools for analysis.
  • Biophysical characterization of transcriptional condensates.
  • Chromatin immunoprecipitation assays.

Expected Profile

Highly motivated and dynamic Ph.D. candidate with great communication skills and a strong interest in unraveling epigenetic mechanisms using multidisciplinary approaches.

Interested candidates, please contact at priyanka.sharma@ipbs.fr for further information. 

Detailed subject pre-proposal

Launch of CARe’s 2024 call for proposals 2nd phase

The pre-selected projects in the framework of CARe’s 2024 call for PhD proposals are available on this link.

PhD candidates for the pre-selected projects will submit the full proposal to Claire Mendoza (claire.mendoza-berrio@univ-tlse3.fr) and Clemence Grosnit (clemence.grosnit@univ-tlse3.fr) using this template.

At this step, PhD candidates must be identified and are asked to send a complete CV. In addition, it is mandatory to provide a full description of the 3-6 months internship, including a signed attestation from the hosting foreign university or from industry.

The files must be submitted as a single PDF before May 10th, 2024. Applicants will defend their proposal on June 4th, 2024, in front of a jury representative of the CARe Graduate School, with delegates from Toulouse partner doctoral schools.

The audition will consist of 12 minutes of presentation and 15 minutes of questions. The presentation and the answers to questions have to be done in English.

The presentation must include, in this order, 1 title slide, 1 slide presenting the candidate, one slide presenting a previous research experience. The rest of the slides are dedicated to the presentation of the project (scientific justification of the research project, strategy, methodology, feasibility and risk management), including a description of the internship abroad or in industry. The following criteria will be evaluated by the jury: discussion of a previous research experience, quality of the oral presentation and of the response to questions.

Several detailed PhD subject pre-proposals and offers are published below. 

I2MC LiMitAging, Toulouse - University of Nantes.pdf
CRCT Melasphinx, Toulouse - Stony Brook University NYC
Toulouse NeuroImaging Center - Softmat, Toulouse
Laboratory of Synthesis and Physico-Chemistry of Molecules of Biological Interest, Toulouse - UCSI University Kuala Lumpur
Center for Integrative Biology, Toulouse - Orebro University, Sweden
IPBS - Team Epigenetic Mechanisms in Cancer, Toulouse
IPBS - Team Epigenetic Mechanisms in Cancer, Toulouse - PhD offer

INTEGRATING MULTI-OMICS AND BIOLOGICAL KNOWLEDGE TO BRIDGE SIGNALLING AND METABOLISM

On Friday, March 22nd, Aurélien Dugourd from the Saez-Rogriguez lab, Heidelberg University will give a talk on how the integration of multi-omics and biological knowledge can bridge signalling and metabolism at 11am in Salle Cazaux, CRCT.

BIO: After he graduated from his Computational Biology master’s degree in 2015, Aurelien Dugourd joined Julio Saez-Rodriguez team as a PhD student. He worked on the development of hybrid mechanistic models, integrating gene regulation, signaling pathways and metabolomics data to explain disease phenotypes, help find new therapeutic targets and predict their potential effect based on a specific patient profile. This led to the development of the tools COSMOS and oCEan. This project was part of the collaborative SyMBioSys ITN project, financed by the European Marie Skłodowska-Curie actions, as well as the SMART-CARE consortium to apply mass-spectrometry-based systems medicine to cancer.
Today, he leads the development and application of methods to extract interpretable mechanistic insights from multi-omic datasets. He especially focuses on leveraging prior knowledge, in the context of signaling and metabolism of complex diseases, such as cancer and development of treatment resistance. He works in collaboration with pharmaceutical partners, notably Pfizer, to support the development of novel cancer treatments and better understand the development of resistances by bringing those methods closer to relevant industrial applications.

Follow the event online here.