Registrations for the first year of the Master’s “Bio – Santé”, Cancer, Ageing and Rejuvenation – CARe Graduate School program
International students registrations are open!
Please send your application by email, in English or French, with the documents listed below as a PDF document to Clémence Grosnit (firstname.lastname@example.org) and Claire Mendoza (email@example.com), indicating in the message your name, first name, e-mail address, home University, and level of study (last diploma).
- A Curriculum vitae (2 pages maximum);
- A cover letter: a motivation letter describing your skills and knowledge in relation with the Master’s as well as your research interests (2 pages maximum);
- University results since high school: undergraduate (Bachelor) and postgraduate (Master 1), as well as academic distinctions;
- A brief description of previously followed university courses, to assess the nature and level of acquired knowledge relevant for this programme;
- A letter of recommendation from an academic faculty member or a past internship supervisor;
- Results of English proficiency test for non-native English candidates (TOEIC > 750 or TOEFL iBT > 85 or IELTS > 6.5).
The deadline for applications is April 30, 2023.
CARe Graduate School’s scholarships
Each year, the CARe Graduate School offers the possibility to international students who have been selected to join the Master’s “Bio-santé” on Cancer, Ageing and Rejuvenation to benefit from a two-year scholarship.
Objective of the call: Allow international CARe students to travel, fund their accommodation and personal expenses during their Master’s studies at the University of Toulouse 3 – Paul Sabatier.
Amount of the scholarship: 7,000 Euros per academic year (14,000 Euros for two years), paid monthly from September to June (700 Euros per month).
A round-trip air ticket will also be covered.
- Hold at least a Bachelor’s Degree in biology, mathematics, computer science, chemistry, physics or related field from a foreign university;
- Have been selected to join the Master’s “Bio-santé” on Cancer, Ageing and Rejuvenation.
A strong preference will be given to candidates living abroad at the moment of their application and travelling to France to register to CARe’s Master.
The second year of the scholarship is subjected to the validation of the first year of the Master’s Degree.
After receiving a positive response to their application to the Master’s “Bio-santé” on Cancer, Ageing and Rejuvenation, international students shall send a letter of interest by email to Claire Mendoza (firstname.lastname@example.org) and Clémence Grosnit (email@example.com), by May 31, 2023.
CARe Graduate School’s internship support
Each year, the CARe Graduate School allows international students to conduct an internship in a CARe’s partner laboratory in Toulouse on Cancer, Ageing and/or Rejuvenation. CARe covers the intern’s gratuities and a round-trip air ticket. The host laboratory may grant additional funding to the intern.
Objective of the call: Allow international students to conduct an internship in a CARe’s partner laboratory in Toulouse.
Amount of the scholarship: The CARe Graduate School will cover the interns’ gratuities to the amount provided by the French law, as well as a round-trip air ticket, for a maximum total amount of 4,500 Euros.
- Hold at least a Bachelor’s Degree in biology, mathematics, computer science, chemistry, physics or related field from a foreign university;
- Be registered in a Master’s Degree (or equivalent) program in a foreign university;
- Be selected to conduct an internship in a CARe’s partner laboratory in Toulouse on Cancer, Ageing and/or Rejuvenation.
Applications are welcomed at any time: after receiving a positive response from the partner laboratory, international students shall send an expression of interest and their internship acceptance letter by email to Clémence Grosnit (firstname.lastname@example.org) and Claire Mendoza (email@example.com).
The CARe Graduate School also offers the possibility to Master 1, Master 2 and PhD students who are affiliated with CARe’s program to receive a financial support (travel and accommodation) to conduct an international internship from two (2) to six (6) months.
Objective of the call: Allow CARe students to fund travel and accommodation expenses abroad to conduct an internship.
Maximum funding per mobility project: maximum 3,600 Euros for three months and maximum 6,600 Euros for six months. See exact funding per destination and internship duration here.
Selection criteria: Applications must be in the field of cancer, aging and/or rejuvenation. Special attention will be given to proposals at the interface of biology and mathematics, computer science, chemistry or physics.
Application process: At least two (2) months before the beginning of their internship, students shall send to Claire Mendoza (firstname.lastname@example.org) and Clémence Grosnit (email@example.com) a short description of their internship project, including:
- Their research topic or programme;
- The host laboratory and institution details;
- The contact details of their internship supervisor;
- The dates of their internship.
Selected students will have the obligation to provide CARe’s Graduate School with their expenses supporting documentation, as well as with their internship agreement, their internship attendance certificate and their internship report.
Thèse financée : Rôle de l’accumulation de cholestérol dans la dysfonction adipocytaire au cours de l’obésité
Unité : Inserm UMR 1087/CNRS UMR 6291 – Institut du Thorax, Nantes
Équipe IV “ Cardiometabolic diseases”
A propos de la Structure
L’institut du thorax est une structure de recherche translationnelle dédiée aux maladies cardiaques, vasculaires, métaboliques et respiratoires.
Reconnu par l’INSERM, le CNRS, l’Université de Nantes et le CHU de Nantes, l’institut du thorax associe recherche fondamentale, programmes
translationnels, activité clinique et formation avancée au sein d’une même structure où cliniciens et scientifiques croisent leurs expertises pour
favoriser l’excellence et l’innovation au travers de programmes multidisciplinaires et offrir aux patients une prise en charge clinique de pointe.
L’obésité est un facteur de risque majeur des complications cardiométaboliques telles que le diabète de type 2 et les maladies cardiovasculaires.
L’hypothèse de la “limite d’expansion du tissu adipeux blanc (TAB)” propose que chaque individu possède une capacité de stockage adipocytaire
propre, qui une fois dépassée, conduit à des dépôts ectopiques de lipides dans différents organes favorisant le développement de
l’insulinorésistance par des mécanismes de lipotoxicité. Dans ce contexte, la dysfonction adipocytaire, qui altère la capacité d’expansion et de
stockage du TAB, contribue au développement des complications métaboliques associées à l’obésité. Alors que de nombreuses études se sont
attachées à décrypter la dysfonction adipocytaire au cours de l’obésité, les mécanismes précurseurs rendant l’adipocyte dysfonctionnel et
insulinorésistant restent, à ce jour, peu connus.
Contexte et objectifs du projet de thèse
Ce projet de thèse vise à établir le rôle du cholestérol dans la dysfonction adipocytaire dans le contexte de l’obésité. Nos données préliminaires,
obtenues sur des modèles cellulaires, murins et chez des patients obèses, montrent que l’accumulation de cholestérol libre adipocytaire favorise
la mise en place de cette dysfonction. Le projet de thèse aura pour objectifs spécifiques de:
1. Comprendre comment l’accumulation de cholestérol libre conduit à la dysfonction de l’adipocyte.
2. Déterminer si l’estérification du cholestérol dans l’adipocyte peut tamponner la toxicité du cholestérol libre.
3. Mettre en place une stratégie de correction de la dysfonction adipocytaire en améliorant la capacité d’estérification du cholestérol.
Le projet dans lequel s’intègre la thèse a pour objectif de proposer de nouvelles interventions thérapeutiques pour corriger les complications
cardiométaboliques associées à l’obésité.
A travers ce projet de thèse, le(la) doctorant(e) développera des compétences expérimentales spécifiques en culture cellulaire, en expérimentation
in vivo et en biochimie.
Etudiant en master 2 en biologie et/ou profil ingénieur sciences du vivant avec une expérience de recherche en biologie/santé. Une connaissance
de la physiopathologie du tissu adipeux et du métabolisme énergétique est attendue. Une connaissance de la biochimie des lipides serait un plus.
Une expérience sur des modèles murins et/ou en culture cellulaire sont attendues.
Début thèse : octobre 2022
Ouverture candidature : dès à présent
Contact : Simon Ducheix (CRCN INSERM –
Equipe IV institut du thorax)
Pour postuler : Envoyer CV et lettre de
motivation à simon.ducheix@univ–nantes.fr
Pour plus d’informations, cliquer ici.
PhD student position offer: Development of a therapeutic screening platform for intestinal pathologies thanks to a controlled environment colon–on–chip (GutScreen)
Equipe ‘Interaction entre l’environnement et l’épithélium intestinal’
Institut de Recherche en Santé Digestive (IRSD)
The intestinal epithelium is one of the main interfaces between the outside world and our internal organism. It establishes a dynamic barrier allowing the absorption of food nutrients and the exclusion of harmful compounds from light, while allowing the collection of antigens within the digestive tract. This ability to control absorption and protect against damage from harmful substances is defined as gut barrier function (IBF). IBF is altered in inflammatory bowel disease (IBD), but also cancer. IBD is characterized by chronic inflammation and impaired intestinal regeneration leading to an abnormal and incomplete healing process. Inflammation can be treated with anti-inflammatories, but no treatment allows the regeneration of the epithelium with all its functional characteristics. The intestinal stem cells (ISC) present in the intestinal crypts ensure the renewal of the entire intestinal mucosa within a week. In IBD, the regenerative capacities of ISCs are impaired. Despite research efforts, the understanding of the mechanisms involved in the regenerative capacities of human ISCs remains partial.
3D intestinal organoids allow the re-creation of intestinal epithelial mini-organs to study the ability of the ISC to reconstitute a fully functional epithelium. However, being cultured in 3D within a matrigel™, they do not correctly reproduce the intestine/colon topology and make access to the luminal compartment difficult. Thus, synthetic in vitro models such as organs-on-chip allowing the control of specific parameters (tissue topology, stiffness and distribution of nutrient fluxes) are necessary to study the light/epithelium interface and the impacts of tissue architecture on the behavior and fate of cells. Indeed, the human colon-on-chip is an innovative technology that has the potential to replace in vivo animal studies with in vitro models that mimic human physiology at basic levels. Organs-on-a-chip are designed to overcome the limitations of two-dimensional (2D) cell culture systems by mimicking 3D tissue organization and microenvironmental signals that are physiologically and clinically relevant. Unlike animal studies, these models can be configured for high-content or high-throughput screening in preclinical drug development.
We have recently patented a colon-on-chip designed to provide dynamic luminal and basal control by injection into the system (culture medium, drugs, dyes, antibodies, microbiota, …) as well as the creation of gradients and the possibility collect and analyze the outgoing flow in real time (metabolic parameters-pH, oxygen, lactate, etc.; analysis by mass spectrometry (MS)). This device, seeded with patient-derived colon organoids and fibroblast cultures (healthy and IBD), will be an innovative and powerful tool to study human intestinal regeneration, as well as the events that affect or may affect the colon epithelium in IBDs such as IBF, interaction with microbiota, and impacts of nutrients/food contaminants/pollutants on the epithelium, as well as drug screening.
The candidate must have validated a Master 2 (or equivalent) with Honors in the fields of cell biology, biochemistry, oncology, physiopathology or biophysics. Ideally, he/she would also have knowledge of primary culture of human cells, transcriptional analyses, biomaterials, image analysis. He/she is motivated, organized, rigorous, autonomous and has an excellent team spirit. Two contacts (former internship supervisors, teachers, etc.) for the student’s recommendation are necessary to validate the application. Please include their contact details in your letter of recommendation.
Contacts and deadline for submitting your application
Please send your CV and a cover letter no later than Wednesday July 20, 2022 to firstname.lastname@example.org and email@example.com
PhD thesis in biomathematics: Morphogenetic emergence across biological scales
Centre for Integrative Biology (CBI), Toulouse, France
Description of the project
During development, dynamic interactions between cells allow the emergence of organ shapes. Because of the diversity of cell properties and behaviors, such as migration, division, or adhesion, complex morphogenetic processes have been difficult to tackle experimentally. We study the development of the posterior part of the vertebrate embryo as it contains progenitor cells that will both specify and form distinct tissues, the neural tube (future nervous system), and the paraxial mesoderm (future vertebrae, muscle, and derm). Using time-lapse movies, we will quantify quail embryonic cells and tissues behavior by image analysis. Based on these quantifications, we will develop agent-based and continuum (PDE) models to understand the relationships between the different levels of organization of our system: cell/cell, cell/tissue, and tissue/tissue interactions. These models will be analyzed theoretically and numerically (qualitative behavior, link between the different models) and tested against our biological data. Altogether, we will be able to combine unique experimental results and theoretical/numerical approaches to understand how distinct cellular behaviors synergize to build embryonic tissues and structures.
Morphogenesis, cell and tissue behavior, self-organization, agent-based modeling, continuum modeling, partial differential equations, numerical simulation, scaling/hydrodynamic limits, free boundary problem, time-lapse imaging, migration.
Romanos M, Allio G, Roussigné M, Combres L, Escalas N, Soula C, Steventon B, Trescases A.,
Bénazéraf B.. Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and
destiny. Elife. 2021 Oct 5;10.
Degond P, Hecht, S, Romanos, M and Trescases, A. Multi-species viscous models for tissue growth: incompressible limit and qualitative behaviour
Conditions and application
The candidate will work in a highly interdisciplinary collaborative context. Image and data analysis will be performed at the Centre for Integrative Biology (CBI) in Toulouse under the supervision of Bertrand Benazeraf. The theoretical side will be supervised by Ariane Trescases at the Institute of Mathematics of Toulouse (IMT).
Candidates must have a Master’s degree or equivalent in mathematics or a subject with a strong mathematical component (e.g. physics, bio-physics, bio-mathematics, engineering, computer science), skills in programming, and experience and/or demonstrate a strong interest in image analysis and morphogenesis. Funding: CNRS PRIME MITI (three years); Start date: Sept/October 2022.
For application send a unique PDF file containing a CV, mark reports since the beginning of higher education, and a motivation letter with 2 reference contacts to firstname.lastname@example.org and email@example.com
MASTER OR PhD
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