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PhD

into labs

research works

The PhD program is devoted to enroll students in various transdisciplinary research topics from very basic science to clinical or pharmacological outcomes. PhD research proposals are under the supervision of CARe-associated research teams from academic laboratories or partner companies. PhD proposals are selected by CARe committees and on line in spring every year. Candidates must send a complete biosketch and will be selected by a mixed board. PhD student will spend a part of the PhD stay abroad.

PhD proposals

The mouth and the biological ageing process: bidirectional influences and biological markers

PhD proposal Supervisor: Jean-Noel Vergnes Team S. andrieu (U1027) Biological ageing is a complex process, influenced by genetic and environmentalfactors. Factors influencing the ageing
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Automatic knowledge extraction and structuration in digital pathology images: applications to decision support tools for diagnosis and complex immunostaining analysis

PhD proposal Supervisors: Pierre Brousset Team P. Brousset (CRCT) Deep convolutional neural networks (CNN) have been tackling, with impressive results, most of the pattern
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Intrinsic abilities and nutrition in population : the role of Reactive Oxygen Species analyzed by mathematical modelling

PhD proposal Supervisors: S. Guyonnet & N. Davezac Team S. Andrieu (U1027) The objective is to study the relationship between nutrition and intrinsic capacities
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Role of the myelomonocytic lineage in Noonan syndrome-associated clinical traits

PhD proposal Supervisor: A. Yart Team P. Valet – I2MC The general aim of the thesis project is to better understand the pathophysiology of
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Epigenetic manipulation in the aging brain: a new way to prevent memory decline

PhD proposal Supervisor: C. Florian Team C. Rampon – CRCA Age-related diseases and age-related cognitive decline have become a major medical, scientific, social and
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Modeling TNF-induced ceramide metabolism changes in T-cell immuno-senescence and resistance of melanoma patients to immune checkpoint inhibitors

PhD proposal Supervisor: B. Segui Team T. Levade – CRCT Cutaneous melanoma is a very aggressive and immunogenic skin cancer that can be treated
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Blood platelets, Thrombosis and Aging: deciphering novel molecular mechanisms for therapy

PhD proposal Supervisor: S. SEVERIN Team B. Payrastre – I2MC The thrombotic risk, mainly due to blood platelet dysfunctions, has a considerable impact in
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Multiomics analysis and modeling to predict metabolic response in the resistance to leukemia therapies

PhD proposal Supervisor: J.E. SARRY Team J.E. Sarry – CRCT Despite a high rate of complete remission after treatment with genotoxic agents, the prognosis
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Adipose tissue microbiota and ageing

PhD proposal Supervisor: J. Galitzky Team A. Bouloumié – I2MC The development of adipose tissue is dependent on its interaction with the environment and
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All CARe PhD PROMOTIONS



  •  Julien Novarino: julien.novarino@outlook.fr

-Supervisor: Dr. Nicolas Fazilleau

-Specialty: Immunology

-Thesis subject: Heterogeneity of follicular CD4 + T lymphocytes controlling B responses

-Laboratory: CPTP – Center for Physiopathology of Toulouse Purpan UMR 1043 – Toulouse in Team 4: Antigen presenting cells and CD4 T responses;

Team leaders: Dr. N. Fazilleau / Dr. S. Guerder


  • Ikram Ayoub: ikram.ayoub@inserm.fr

-Supervisors: Dr. Roland Liblau; Dr. Abdelhadi Saoudi

-Specialty: Immunology

Thesis subject: Study of specific immune responses to antigens in the older people and patients suffering from neuroinflammatory diseases

-Laboratory: CPTP – Center for Physiopathology of Toulouse Purpan UMR 1043 – Toulouse in Team 5 Inflammatory Diseases of the Central Nervous System: Mechanisms and Therapies;

Team leaders : Dr. R. Liblau /Dr. A. Saoudi


  • Emmanuel Gonzales-Bautista: emmanuel.scout@gmail.com

-Supervisors: Dr. Sandrine Andrieu; Dr. Philippe De Souto Barretto

-Thesis subject: Measuring intrinsic capacity in the context of integrated care for the older people.

-Laboratory: UMR 1027: Epidemiology and analyzes in public health: risks, chronic diseases and disabilities in Team MAINTAIN – MAintain Functions and INTrinsec capacities with Aging : Preventive and Personalized INterventional Research; 

Team leader: Dr. Sandrine Andrieu


  • Mathieu Virazels: mathieu.virazels@inserm.fr

-Supervisors: Dr. Bruno Ségui; Dr C. Colacios

-Specialty: Oncology

-Thesis subject: Thesis subject: Role of TNF-alpha and sphingolipids in the response of melanoma to “immune checkpoint” inhibitors

-Laboratory: CRCT –Toulouse Cancer Research Center in Team 4: Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy; 

Team leaders: Dr. Bruno Ségui / Dr. Nahtalie Andrieu

 

 

 

 

 

 
  •  kévin Cortacero: kevin.cortacero@inserm.fr

-Supervisors: Dr. S. Valituti, CRCT; Dr. Sylvain CUSSAT-BLANC, IRIT: “Toulouse Computer Science Research Institute”

-Specialty: Immunology

-Thesis subject: The ontology of lytic synapses: an interdisciplinary approach for the study of cytotoxic T lymphocytes and tumor cell control in the tissues of cancer patients

-Laboratory: CRCT:”Toulouse Cancer Research Center” in Team 20: Molecular dynamics of lymphocyte interactions
Team leaders: Dr. Salvatore Valittuti


  • Ruchan Ekren: ruchan.ekren@inserm.fr

-Supervisor: Dr. Ludovic Martinet

-Specialty:

-Thesis subject: Transcriptomic program of lymphocytes T CD8+ in multiple myelome

Laboratory: CRCT:”Toulouse Cancer Research Center” in Team 13:  Genomics and immunology of myeloma

Team leaders:Dr. H. Avet-Loiseau / Dr. Ludovic Martinet


  • Lucie Rapp: lucierapp@hotmail.fr

-Supervisor: Dr. Jean-Noel Vergnes

-Specialty:

-Thesis subject: The mouth and the biological ageing process: bidirectional influences and biological markers

-Laboratory:

Team leaders:


  • Camille Champigny: champigny.c@chu-toulouse.fr

-Supervisors: Dr. Noélie Davezac, CRCA, Dr. Sophie GUYONNET, UMR 1027 

-Specialty:  Aging sciences – Gerosciences

-Thesis subject: Intrinsic abilities and nutrition in population : the role of Reactive Oxygen Species analyzed by mathematical modelling

-Laboratory: CRCA– Center for Research on Animal Cognition UMR 5169 – Toulouse in Team: Mithochondria, neuronal plasticity and neurodegeneration (MINDING)

Team leaders:Dr. Pascale Belenguer


  • Shixing Feng: fsx1992@outlook.com

-Supervisor: Dr. Fatemeh NOURHASHEMI

-Specialty:

-Thesis subject: Impact of Chinese medicine on cognitive alterations 

-Laboratory:UMR 1027″ Epidemiology and analyzes in public health: Risks, chronic diseases and disabilities” in Team: MAINTAIN – MAintain Functions and INTrinsec capacities with Aging : Preventive and Personalized INterventional Research
 
Team leaders: Dr.
Sandrine Andrieu


  • Wan-Hsuan LU: penizoe@gmail.com

-Supervisor: Dr. Philipe de Souto Barretto

-Specialty:

-Thesis subject: Epidemiological approach to intrinsic capacity and inflammation

-Laboratory: -Laboratoy:UMR 1027″ Epidemiology and analyzes in public health: Risks, chronic diseases and disabilities” in Team: MAINTAIN – MAintain Functions and INTrinsec capacities with Aging : Preventive and Personalized INterventional Research
 Team leader:
Dr. Sandrine Andrieu


  • Célia Bak: celia.bak@univ-tlse3.fr

-Supervisors: Dr. Claire RAMPON, Dr. Cédrick Florian

-Specialty: Neurosciences

-Thesis subject: Study of epigenetic mechanisms in the aged brain: a new way to prevent cognitive decline

-Laboratory: CRCA – Center for Research on Animal Cognition UMR 5169 – Toulouse in Team: Revealing Memory Mechanisms of the Brain (REMEMBeR)

Team leader: Dr. Claire RAMPON


  • Matthieu Genais: matthieu.genais@gmail.com

-Supervisors: Dr. Bruno Ségui, Dr. Vera Pancaldi

-Specialty:  Bioinformatics, Genomics and biology of systems

-Thesis subject: Prediction of clinical response to immunotherapy in patients with advanced melanoma: a machine learning approach using multi-omics

-Laboratory: CRCT:”Toulouse Cancer Research Center” in Team 4: Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy

Team leaders: Dr. Bruno Ségui / Dr. Nathalie Andrieu


  • Laurène Mazeyrie: laurene.mazeyrie@inserm.fr

-Supervisor: Dr. Armelle Yart; Dr. Thomas Edouard

-Specialty:

-Thesis subject: Role of the myelomonocytic lineage in Noonan syndrome-associated clinical traits

Laboratory: UMR 1048 Inserm / Université Toulouse III Paul Sabatier, 1 avenue du Professeur Jean Poulhès 31432 Toulouse in Team 3: Adipocyte secretions, obesities and related diseases

Team leader: Dr. Philippe Valet


  • Léa Da Costa Fernandes: dacosta.lea@hotmail.com

-Supervisor: Dr. and Deputy Director of STROMALab: Béatrice Cousin; Dr. François Pérès: The National School of Engineers of Tarbes (ENIT) (INPT)

-Specialty: Physiopathology

-Thesis subject: Modeling of the PROnostic and DIagnosis of Tissue REgeneration in Aging (PRODIRE)

-Laboratory: RESTORE: STROMALab – Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS in Team 1 : Plasticity of adipose tissue

Team leader: Dr. Béatrice Cousin 


  • Pilar Ortega: maria-del-pilar.ortega-arevalo@univ-tlse3.fr

-Supervisor: Dr. Pierre Brousset: CRCT; Dr. Jean-Marc Alliot: IRIT

-Specialty:

-Thesis subject: Automatic knowledge extraction and structuration in digital pathology images: applications to decision support tools for diagnosis and complex immunostaining analysis

Laboratory: CRCT: Toulouse Cancer Research Center in Team 7: RNA Biology in hematological tumors

Team leaders: Dr. S Pyronnet


  • Mélanie Escudero

-Supervisors: Dr. and Director of STROMALab: Louis Casteilla; Dr. Laurent MALAQUIN LAAS

-Specialty: Metabolic and Cardiovascular Diseases

-Thesis subject: Microfabrication of a 3D microphysiological vascularized brown like adipose tissue to treat metabolic and age related dysfunctions

-Laboratory: RESTORE: STROMALAB – Cellules stromales, homéostasie, plasticité et réparation tissulaire UMR 5273 – TOULOUSE

Team leader: Dr. Louis Casteilla


  • Anastasia Pacary: anastasia.pacary@inserm.fr

-Supervisor: Dr. Marielle Ousset StromaLab, RESTORE

-Specialty:

-Thesis subject: Mechanisms of tissue stiffness and regeneration / rejuvenation

-Laboratory: RESTORE: STROMALAB – Cellules stromales, homéostasie, plasticité et réparation tissulaire UMR 5273 – Toulouse,  in Team 1 :  Plasticity of adipose tissue, Aim 1 : Repair / Regeneration and ASC biology

Team leader: Dr. Louis Casteilla


  • Clémence Bolut: clem.bolut@hotmail.fr

-Supervisors: Dr. and Director of STROMALab: Louis Casteilla; Dr. David Simoncini:  IRIT

-Specialty:

-Thesis subject: Image processing, calibration

-Laboratory: RESTORE: STROMALAB – Cellules stromales, homéostasie, plasticité et réparation tissulaire UMR 5273 – Toulouse 

Team leader: Dr. Louis Casteilla


  • Pauline Chassonery: pauline.chassonnery@ens-cachan.fr

-Supervisors: Dr. and Director of STROMALab: Louis Casteilla;  Dr. Diane Peurichard: INRIA

-Specialty:

-Thesis subject: 3D models, digital avatar

-Laboratory: STROMALAB – Cellules stromales, homéostasie, plasticité et réparation tissulaire UMR 5273 – Toulouse 

Team leader:  Dr. Louis Casteilla


  • Snigdha Nitin Rao: snigdharao@gmail.com

-Supervisors: Dr. Joost Schanstra; Biology PhD student in the Toulouse Inserm unit U1048:  Julie Belliere

-Specialty:

-Thesis subject:

-Laboratory: Institute of Cardiovascular and Metabolic Diseases (I2MC – UMR1048) in Team 12: Renal fibrosis: mechanism and detection

Team leader: Dr. Joost Schanstra


  • Luana Cintori: cintoriluana@gmail.com

-Supervisor: Dr. Yvan Canitrot

Specialty: Cellular Biology

Thesis subject: Study of the management of targeted oxidative damage to DNA

-Laboratory: CBI: Toulouse Center for Integrative Biology in Team Chromatin and cell proliferation

Team leaders: Dr. Didier Trouche


  • Jacobo Solorzano: Jacobo.solorzano@inserm.fr

-Supervisors: Dr. Corinne Bousquet, Dr. Vera Pancaldi

-Specialty: Bioinformatics, Genomics and Biology of Systems

-Thesis subject: Translation Characterization of stroma from pancreatic cancer, towards a new approach to classification

-Laboratory: CRCT: Toulouse Cancer Research Center in Team 6: Microenvironment and therapeutic resistance in pancreatic neoplasms

Team leaders:Dr. Corinne Bousquet