PhD

PhD Proposals

Congratulations to our 5 new CARe doctoral grant recipients!

CARe is proud to enroll five new students in its transdisciplinary PhD program, devoted to the training of students in multidisciplinary research topics, from
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PhD fellowship at the interface between Cancerology / Immunology / Vascular biology M/F

3 years full time PhD student position funded by LABEX TOUCAN: Laboratoire d’Excellence Toulouse Cancer starting date: October 1st, 2021 is available in the
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Multi-OMICs to unveil the role of lipid metabolism in the control of senescence and cellular plasticity in melanoma

PhD proposal PhD supervisor : Nathalie ANDRIEU, CRCT: Toulouse Cancer Research Center, Toulouse, France  PhD co-supervisor : Gemma Fabrias, IQAC-CSIC: Institute for Advanced Chemistry
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into labs

research works

All CARe PhD promotions

Ikram Ayoub, Study of specific immune responses to antigens in the older people and patients suffering from neuroinflammatory diseases”, Infinity, Team 4: Inflammatory Diseases of the Central Nervous System: Mechanisms and Therapies, Thesis supervisors: Roland Liblau (Infinity), Abdelhadi Saoudi (Infinity)

Emmanuel Gonzales-Bautista, “Measuring intrinsic capacity in the context of integrated care for the older people”, CERPOP, Team MAINTAIN – MAintain Functions and INTrinsec capacities with Aging: Preventive and Personalized INterventional Research, Thesis supervisors: Sandrine Andrieu (CERPOP), Philipe de Souto Barreto

Julien Novarino, Heterogeneity of follicular CD4 + T lymphocytes controlling B responses”, Infinity, Team 11 : Antigen presenting cells in T Cell Responses, Thesis supervisors: Nicolas Fazilleau (Infinity), Sylvie Guerder

Mathieu Virazels, “Role of TNF-alpha and sphingolipids in the response of melanoma to ‘immune checkpoint’ inhibitors”, CRCT, Team 4: Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy, Thesis supervisors: Bruno Ségui (CRCT), Céline Colacios (CRCT)

Elissa Andraos, “Deciphering the link between resistance and intratumoral heterogeneity in anaplastic large cell lymphoma expressing the oncogenic tyrosine kinase ALK by single-cell transcriptomic analysis and multiparameter phenotyping”, CRCT, Team 7: RNA biology in hematological tumors, Thesis supervisors: Fabienne Meggetto (CRCT), Stéphane Pyronnet (CRCT)

Célia Bak, Study of epigenetic mechanisms in the aged brain: a new way to prevent cognitive decline”, CRCA, Team: Revealing Memory Mechanisms of the Brain (REMEMBeR), Thesis supervisors: Claire Rampon (CRCA), Cédrick Florian (CRCA)

Clémence Bolut, “Image processing and calibration”, Restore – Stromalab, Thesis supervisors: Louis Casteilla (Restore), David Simoncini (IRIT)

Camille Champigny, Intrinsic abilities and nutrition in population : the role of Reactive Oxygen Species analyzed by mathematical modelling”, CRCA, Team: Mithochondria, neuronal plasticity and neurodegeneration (MINDING), Thesis supervisors: Noélie Davezac (CRCA), Sophie Guyonnet (Toulouse University Hospital)

Pauline Chassonery, 3D models, digital avatar, Restore, Stromalab, Thesis supervisors: Louis Casteilla (Restore), Diane Peurichard (INRIA)

Luana Cintori, Study of the management of targeted oxidative damage to DNA, CBI, Team Chromatin and cell proliferation, Thesis supervisor: Yvan Canitrot (CBI)

Kévin Cortacero, The ontology of lytic synapses: an interdisciplinary approach for the study of cytotoxic T lymphocytes and tumor cell control in the tissues of cancer patients, CRCT, Team 20: Molecular dynamics of lymphocyte interactions, Thesis supervisors: Salvatore Valitutti (CRCT), Sylvain Cussat-Blanc (IRIT)

Léa Da Costa Fernandes, “Modeling of the PROnostic and DIagnosis of Tissue REgeneration in Aging (PRODIRE)”, Restore, Team 1: Plasticity of adipose tissue, Thesis supervisors: Béatrice Cousin (Restore), François Pérès (National School of Engineers of Tarbes)

Ruchan Ekren, Multimodal investigation of the transcriptomic program of lymphocytes T CD8+ and NK cells in multiple myeloma”, Laboratory: CRCT, Team 13: Genomics and immunology of myeloma, Thesis supervisors, Ludovic Martinet (CRCT),  Vera Pancaldi (CRCT)

Mélanie Escudero, Microfabrication of a 3D microphysiological vascularized brown like adipose tissue to treat metabolic and age related dysfunctions”, Restore, Stromalab, Thesis supervisors: Louis Casteilla (Restore), Laurent Malaquin (LAAS)

Matthieu Genais, Prediction of clinical response to immunotherapy in patients with advanced melanoma: a machine learning approach using multi-omics”, CRCT, Team 4: Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy, Thesis supervisors: Bruno Ségui (CRCT), Vera Pancaldi (CRCT)

Wan-Hsuan Lu, Epidemiological approach to intrinsic capacity and inflammation”, CERPOP, MAINTAIN Team, Thesis supervisor: Philipe de Souto Barreto

Laurène Mazeyrie, Role of the myelomonocytic lineage in Noonan syndrome-associated clinical traits”, I2MC, Team 3: Adipocyte secretions, obesities and related diseases, Thesis supervisors: Armelle Yart (Restore), Thomas Edouard

Snigdha Nitin Rao, Targeting immunosenescence to prevent kidney disease in elderly patients, I2MC, Team 12: Renal fibrosis: mechanism and detection, Thesis supervisors: Joost Schanstra (I2MC), Julie Belliere (I2MC)

Anastasia Pacary, Mechanisms of tissue stiffness and regeneration / rejuvenation”, Restore, Team 1: Plasticity of adipose tissue, Thesis supervisors: Marielle Ousset (Restore), Jenny Paupert (Restore)

Lucie Rapp, The mouth and the biological ageing process: bidirectional influences and biological markers, CERPOP, MAINTAIN Team, Thesis supervisor: Jean-Noël Vergnes (CERPOP)

Jacobo Solorzano, Translation Characterization of stroma from pancreatic cancer, towards a new approach to classification”, CRCT, Team 6: Microenvironment and therapeutic resistance in pancreatic neoplasms, Corinne Bousquet (CRCT), Vera Pancaldi (CRCT)

Marion Stephan, “Global Redox Potential : Biomarker of the cellular environment homeostasis”, Restore, Thesis supervisors: Cédric Dray (Restore), Pierre Gros


Sanzhar Aitbay, “Bio-Mechanical stress & Signal integration by PI3Ks for the control of tumour growth”, CRCT, Team SydDYN Integrated cell signaling & PI3Ks, Thesis supervisors: Julie Guillermet-Guibert (CRCT), Morgan Delarue (LAAS)

Saber Amri, “Control of neuroinflammation with bi-therapeutic agents”, Infinity, Team 5, Thesis supervisors: Rémy Poupot (Infinity), Jérôme Ausseil (Infinity)

Sébastien Auber, “Deciphering the mechanisms of transcription-coupled DSB at enzymatically-induced and endogenous neuronal DSBs by high throughput genomics”, CBI, Team Chromatin & DNA Repair, Thesis supervisors: Gaëlle Legube (CBI), Raphaël Mourad (CBI). Co-tutorship: Huberchet Institute, Utrecht, Netherlands

Silia Ayadi, “Identification and characterization of new bioactive lipids”, CRCT, Team INOV, Cholesterol Metabolism and Therapeutic Innovations, Thesis supervisor: Marc Poirot (CRCT)

Mohammed Hussein Baz, “Laboratory-on-a-chip for the separation of adipose stem cells”, LAAS, Thesis supervisors: Anne-Marie Gué (LAAS), Coralie Sengenes (Restore)

Chloé Brodeau, “Human skin fibroblasts as indicators of physiological age and frailty”, Restore, Metabolink, Thesis supervisors: Louis Casteilla (Restore), Isabelle Ader (Restore)

Garance Castino, “The mitochondrial metabolism of satellite cells: its influence on post-exercise muscular regeneration in aged subjects”, Restore, Metabolink, Thesis supervisors: Cédric Dray (Restore), Philipe de Souto Barreto

Chiara Cecchin, “Stroma, immunity and metabolism as key understanding of periodontal potential loss with ageing”, Restore, GOT-IT, Thesis supervisors: Philippe Kemoun (Restore), Valérie Planat (Restore)

Maria Chaouki, “Treg evolution in B cell lymphoma patients under PI3Kδ inhibition”, CRCT, SigDYN Integrated signalling & PI3K, Thesis supervisors: Julie Guillermet-Guibert (CRCT), Loïc Ysebaert (CRCT)

Lucas Charpin, “Laboratory-on-a-chip for the separation of adipose stem cells”, LAAS, Thesis supervisors: Anne-Marie Gué (LAAS), Emmanuelle Trévisiol (TBI)

Emmanuel Doumard, “How to explore physiological ageing? A new framework for an in-depth explainability of machine learning models”, IRIT, SIG Team, Thesis supervisors: Chantal Soulé-Dupuy (IRIT), Paul Monsarrat (Restore)

Emma Grandgirard, “Investigating the stroma heterogeneity of adipose tissue using AI-based label free imaging : a predictive marker of frailty ?”, Restore, Stromagics, Thesis supervisors: Coralie Sengenes (Restore), Mathieu Serrurier (IRT Saint-Exupéry, ANITI Team / DEEL)

Alexis Hucteau, “In silico, epigenomic and functional investigations of resistance to IDH inhibitors in acute myeloid leukemia”, CRCT, MetAML, Thesis directors: Jean-Emmanuel Sarry (CRCT), Vera Pancaldi (CRCT)

Nikolaos Kontopoulos, “Molecular basis of oncolytic virus tropism in pancreatic cancer”, CRCT, Thesis directors: Pierre Cordelier (CRCT), Louis Buscail (CRCT)

Laura Lauture, “In vivo study of Gilteritinib resistance in acute myeloid leukemia”, CRCT, MetAML, Thesis director: Jean-Emmanuel Sarry (CRCT)

Léa Magne, “Modeling tissue architecture in colorectal physio(patho)logy by image analysis”, IRSD – Inserm, ICA – CNRS, Thesis directors: Audrey Ferrand (IRSD), Florian Bugarin (ICA)

Lisa Mary, “Multi-OMICs to unveil the role of lipid metabolism in the control of senescence and cellular plasticity in melanoma”, CRCT, Melasphinx, Thesis director: Nathalie Andrieu (CRCT)

Rémy Montane, “Impact of adipose tissue on systemic redox homeostasis during ageing”, Restore, Metabolink, Thesis directors: Audrey Carrière (Restore) Isabelle Ader (Restore)

Margaux Oberling, “Investigating the role of alternative splicing in metabolic flexibility and chemotherapy resistance in acute myeloid leukemia”, CRCT, METAML, Thesis director: Margherita Grisi (CRCT)

Gonçalo Pomba de Almeida, “Systemic redistribution of metabolic flux by chemotherapy in acute myeloid leukemia”, CRCT, Metabolink, Thesis directors: Jean-Charles Portais (CRCT), Jean-Emmanuel Sarry (CRCT)

Elise Ponthier, “Development of microphysiological systems by 3D printing for the study of stem cells and the modeling of intestinal tumorigenesis”, CBI, LAAS, Thesis directors: Arnaud Besson (CBI), Laurent Malaquin (LAAS)

Célia Ramade, “Analysis of T cell responses by omics approaches to understand the mechanisms of resistance to immunotherapy in bronchial and urothelial cancers”, CRCT, T2i Team, Thesis director: Maha Ayyoub (CRCT)

Ophélie Thomas-Chemin, “AutoBioTip: automation of mechanobiological measurements by AFM”, LAAS, Elia, Thesis directors: Etienne Dague (LAAS), Emmanuelle Trévisiol (LAAS)

Haomiao Wang, “Multimodal dataset analysis support system for clinical and biological biomarker detection: proof of concept in oral medicine – PREDINSIGHT 4-D”, Restoire, IRIT, Thesis directors: Paul Monsarrat (Restore), Julien Aligon (IRIT)

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